Pregnenolone, a steroid hormone precursor involved in the synthesis of other hormones like cortisol, estrogen, and testosterone, is sometimes used as a supplement to support hormonal balance, cognitive function, and energy. While it may have benefits, it can also cause side effects, particularly if taken at high doses or for extended periods. Here are some side effects to watch for:

Common Side Effects

  1. Hormonal Imbalance Symptoms

    • Acne

    • Oily skin

    • Facial hair growth (in women)

    • Menstrual irregularities

  2. Mood Changes

    • Irritability

    • Anxiety

    • Depression or mood swings

    • Agitation

  3. Sleep Issues

    • Insomnia or difficulty falling asleep

    • Restlessness

  4. Neurological Symptoms

    • Headaches

    • Dizziness

    • Difficulty concentrating ("brain fog")

  5. Gastrointestinal Issues

    • Nausea

    • Upset stomach

Serious Side Effects (Rare)

  1. Hormone-Related Risks

    • Exacerbation of conditions sensitive to hormones (e.g., estrogen-sensitive cancers, endometriosis, or PCOS).

    • Gynecomastia (breast tissue growth in men)

  2. Cardiovascular Effects

    • Palpitations

    • High blood pressure (less common)

  3. Allergic Reactions

    • Rash, itching, or swelling

    • Severe dizziness or difficulty breathing (seek medical attention immediately)

Considerations

  • Interactions with Medications: Pregnenolone may interact with hormonal therapies, antidepressants, or corticosteroids. Always consult a healthcare provider if you’re taking other medications.

  • Long-Term Use Risks: Extended use can affect natural hormone production and lead to dependency or suppression of the body's ability to produce pregnenolone.

Precautions

  • Pregnant or breastfeeding individuals should avoid pregnenolone unless directed by a healthcare provider.

  • Individuals with hormone-sensitive conditions or a history of hormone-related cancers should consult a doctor before use.

Dosing

  • Mild to Moderate dosing depends for each person usually ranging from 20mg to 100mg. If concerned start low and work up and monitor side effects above.

    If you experience significant or persistent side effects, discontinue use and consult a healthcare professional. It’s advisable to start with a low dose and monitor for adverse reactions.